مقاله Impact of Cardiovascular Risk on the Relative Benefit and Harm of Intensive Treatment of Hypertension

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مقاله Impact of Cardiovascular Risk on the Relative Benefit and Harm of Intensive Treatment of Hypertension عنوان انگلیسی مقاله Impact of Cardiovascular Risk on the Relative Benefit and Harm of Intensive Treatment of Hypertension  چکیده مقاله ی انگلیسی Background The lower rate of primary outcome events in the intensive treatment group in SPRINT (Systolic Pressure Intervention Trial) was associated with increased clinically significant serious adverse events (SAEs). In 2017, the American College of Cardiology/American Heart Association issued risk-based blood pressure treatment guidelines. The authors hypothesized that stratification of the SPRINT population by degree of future cardiovascular disease (CVD) risk might identify a group which could benefit the most from intensive treatment.  Objectives This study investigated the effect of baseline 10-year CVD risk on primary outcome events and all-cause SAEs in SPRINT.  Methods Stratifying by quartiles of baseline 10-year CVD risk, Cox proportional hazards models were used to examine the associations of treatment gr ...

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